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ItemA Study on the Changes in the First-line Coagulation Screening Tests in Sudanese Sickle Cell Disease Patients requirement for the degree of Bachelor with honours in Haematology and Immunohaematology July(university of khartoum, 2011)Sickle cell disease is an inherited disease characterized by a complex and varied physiopathology. Apart from the sickle red blood cells are responsible for vascular occlusion and hemolytic anemia. Changes in the coagulation system seem to play an important role in the clinical manifestations of this disorder. This study aimed to determine the changes in first-line coagulation screening tests in Sudanese sickler patients. Forty patients with SCD of both sexes with ages ranged between 9 months and 18 years, admitted to Um Durman Children Emergency Hospital from January to March 2011, were included in this cross-sectional study. These were either during crisis state or in the steady state. Eleven healthy controls matched with ages and genders of patients were used for comparison. Blood samples from both groups were collected and investigated for CBC, PT, aPTT, TcT, and Fbg concentrations. The study revealed that, in comparison with control means, the mean of Plts count was elevated (P=0.003), TcT and aPTT were significantly low (P=0.00) (P=0.013) respectively, while there were no significant changes in PT clotting times (P=0.641) and fibrinogen concentrations (P=0.212). These results were the same in patients during crisis and those in steady state. The study concluded that these is hypercoagulable state in SCD patients indicated by shortened TcT and aPTT clotting times, these findings were not associated with severity of the anaemia.
Itemcompairson between manual semi manual electronic techniques(university of khartoum, 2014)(100) patients whose full blood count were done by Sysmex kx- 21 showing normal Hb,Hct were screened for results of Red Blood Cells(RBCs) indices. (76) of them showed normal indices as well, while (24) showed low indices despite normal Hb and Hct. Manual Hb, PCV and RBCs indices were done in these (24) subjects. Again, by a semi manual technique the RBCs indices were calculated for those (24) patients, using an automated RBCs count. Hb values were similar by both techniques .PCV, RBCs and indices showed significant difference between manual and automated techniques, but the indices were still lower than normal by both. These findings indicate that the results of the Sysmex kx-21 are actually valid. However the causes of such low indices in presence of normal Hb should be investigated.