University of Khartoum

Gum Arabic in the Scope of its Physico-Chemical Properties, Bacterial Load and Supplementation in Therapy of Chronic Renal Failure

Gum Arabic in the Scope of its Physico-Chemical Properties, Bacterial Load and Supplementation in Therapy of Chronic Renal Failure

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Title: Gum Arabic in the Scope of its Physico-Chemical Properties, Bacterial Load and Supplementation in Therapy of Chronic Renal Failure
Author: Amira Abdel Azeem Ahmed, Behairy
Abstract: This work was conducted in 2000, which deals with comparative study between the commercial gum Arabic samples and the authentic ones in the scope of their physico-chemical properties and bacterial load to determine the purity and safetiness of the commercial samples. The effect of ingestion of 25g/day processed gum Arabic for 28-days on the levels of urea, creatinine, haemoglobin percentage and minerals (Na+1, K+1, Ca+2 and P+5) in the blood of healthy and chronic renal failure subjects. The effects of this dose on the contents of protein and volatile fatty acids in their faeces and polyamines in their blood as metabolic products in their colon. The domination of Klebsiella sp. over E. coli after ingestion of gum Arabic by those subjects. The proximate analysis for each 25 samples from the commercial and authentic Acacia Senegal gum revealed that, the moisture percentage and the pH value were more in the commercial samples than in the authentic ones. Whereas, the ash percentage, specific rotation, nitrogen and protein content were less in the commercial samples than in the authentic ones. All these values were significantly different, except the nitrogen and the protein, but inspite of this they were laid within the range specified by the JECFA. The bacterial load in the nodules of the commercial and authentic gum Arabic samples was more in the outer surface than in the cortex, which is completely sterile. With gum processing the bacterial load was decreased. The major bacterial isolates from gum arabic were Gram-positive Bacillus spp. B. mycoides and B. licheniformis represents the highest percentage of isolates in all forms of gum arabic samples studied. Whereas, Gram-positive cocci; Staphylococcus caseolyticus, represent the minor bacterial isolates. Coliforms were not detected. The effect of ingestion of 25g/day gum arabic for 28-days by healthy and chronic renal failure subjects revealed the following when compared with the pre-gum arabic periods. No side effects were observed except few abdominal troubles either in the first period or in the second one. The changes in blood composition for Hb%, K+1, Na+1, Ca+2 and P+5 levels were laid within the normal range except P+5 in chronic renal failure subjects, it was high . About more than 50% of chronic renal failure subjects showed an increase in the level of K+1, Na+1 and P+5, whereas healthy subjects showed that increased only for P+5. The BUN was decreased in 33.3% of chronic renal failure subjects and in 20% of healthy ones. No obvious correlation was observed between the total acids, volatile fatty acids and nitrogen content in the faeces and the BUN inspite of the increased in the total acids, volatile fatty acids and nitrogen content in the faeces of some chronic renal failure and healthy subjects during the study period. Formation of polyamines was not observed in the sera of these subjects either before or after ingestion of gum Arabic. The domination of Klebsiella sp. over the other Enterobacteriaceae (e. coli, Pseud. sp. and Staph. sp.) was not due to bacteriocine effect. It was suggested to be due to the lowering in pH when gum Arabic was fermented in the colon or due to the release of urease enzyme from Klebsiella sp. and hence formation of ammonia which elevate the pH of the colon
URI: http://khartoumspace.uofk.edu/handle/123456789/11372
Date: 2015-05-25


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