University of Khartoum

Sero-Epidemiological Studies on Trypanosomiasis Situation in Southern Sudan.

Sero-Epidemiological Studies on Trypanosomiasis Situation in Southern Sudan.

Show full item record

Title: Sero-Epidemiological Studies on Trypanosomiasis Situation in Southern Sudan.
Author: Atif El Amin Abdel Gadir, Gadir
Abstract: Sleeping sickness surveys using Card Agglutination Test for Trypanosomiasis (CATT) in Bahar Eljebel State and Eastern Equatoria State showed 65/321 (20.2%) and 26/183 (14.2%) positive cases. Surveys carried out in displaced people camps and prisoners in Khartoum State, who originated form endemic areas in southern States, showed 60/ 211 (28.4%) and 38/144 (26.4%), respectively. Prevalence rate was higher among males than females in Bahar Eljebel State, Equatoria State and Khartoum State (30.7%, 15.8% and 36.1% in males, respectively) and (16.3%, 10% and 21.8% in females, respectively). More positive cases were detected by CATT in Bahar Eljebel, Eastern Equatoria State showed an increase in concentration of total serum proteins and serum globulins in positive cases of sleeping sickness using CATT, but no changes were observed in serum ions values (sodium, potassium, calcium and zinc). A comparison between CATT and card Indirect-Agglutination Antigen Test for Trypanosomiasis (CIATT) for diagnosis of sleeping sickness was done in 250 serum samples form displaced people camps in Khartoum and Omdurman women prison, the result showed 71 (28%) positive by CATT and only 15 (6%) positive by CIATT. A comparison between CATT and CIATT for diagnosis of sleeping sickness on serum samples or dried blood samples on filter papers obtained from 28 samples from displaced people camps in Khartoum State and Omdurman women prison gave 17 (60.9%) positive by CATT and 15 (53.6%) positive by CIATT from serum samples. Dried blood samples showed only 3 (10.7%) positive cases by CATT and there were no positive cases by CIATT. There is no significant cross reactivity between human immunodeficiency virus (HIV) infection and sleeping sickness using CATT in non-endemic areas of sleeping sickness. CATT and CIATT were found similar in their cross reactivity which resulted in detection of false positive reactors to sleeping sickness from patients with leishmaniasis and malaria from non-endemic areas of sleeping sickness (46% and 42.9% detected by CATT, respectively) and (28% and 34.3% detected by CIATT, respectively). Suratex and CIATT were found to be similar in diagnosis of T. evansi infection in camels from natural infection (7.3% and 6%, respectively). Suratex and CATT were significantly different in diagnosis of T. evansi infection in camels from natural infection (7.3% and 25.6%, respectively). In Bovine sera significant differences were found between CATT and CIATT (92% for CATT and 29% for CIATT). However, all serum samples were parasitologically negative, and they were collected from cattle in non-endemic areas of sleeping sickness.
URI: http://khartoumspace.uofk.edu/handle/123456789/14228
Date: 2015-06-23


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account