University of Khartoum

Pathogenicity of Trypanosoma evansi in Goats, Rabbits and Guinea pigs

Pathogenicity of Trypanosoma evansi in Goats, Rabbits and Guinea pigs

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Title: Pathogenicity of Trypanosoma evansi in Goats, Rabbits and Guinea pigs
Author: Nahid Abdel Gafoor Abdel Gadir, Abdel Gadir
Abstract: Three different species of animals were selected to demonstrate effect of T. evansi. Goats, rabbits and Guinea pigs were used. Rabbits developed T. evansi parasitaemia in the blood Goats and Guinea pigs did not show parasitaemia in their blood although they developed anaemia, which represented the main symptom of the disease. Follow up of erythrocyte count, packed cell volume and white blood cell count was done in the three animals. RBCs markedly dropped from the control at initial days of infection in goats, while WBCs had no significant change. This continued for four weeks from the infection after which, there was no decline in PCV and RBCs values. The animals became stable but still anaemic. Rabbits and Guinea pigs also underwent significant changes in haematological picture, where in the two species a decrease in PCV and Hb parameters was observed. In the groups injected twice intramuscularly for both rabbits and Guinea pigs the drop in PCV, Hb and body weight was more pronounced than that for those injected subcutaneously and then intravenously. The decrease in these parameters continued till the end of the experiments. Histopathological examination revealed remarkable internal lesions in rabbits and Guinea pigs. The spleen was congested and there was excessive deposition of haemosidrin pigment in the splenic parenchyma. Kidneys were also congested with massive cortical haemorrahages and presence of RBCs inside the glomerular tufts. Congestion was also observed in the cerebral cortex, and meningeal blood vessels. The choroid plexus was severely congested and infiltrated with lymphocytes in T. evansi-infected Guinea pigs.
URI: http://khartoumspace.uofk.edu/handle/123456789/14239
Date: 2015-06-23


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