University of Khartoum

Pharmacological and Toxicological Effects or Balanites Aegyptiaca on Laboratory Animals

Pharmacological and Toxicological Effects or Balanites Aegyptiaca on Laboratory Animals

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Title: Pharmacological and Toxicological Effects or Balanites Aegyptiaca on Laboratory Animals
Author: Awatif Mohammed Iskander, Iskander
Abstract: The pharmacological, toxicological, pathological, hormonal and growth-promoting effects of Balanites aegyptiaca kernel and mesocarp in laboratory animals were studied. Substitution of 10 or 20% of chicks standard ration by mesocarp resulted in a significant increase in body weight when compared to chicks receiving the standard ration. However, substitution of 20% of the standard ration by mesocarp powder was not advantageous over the 10% substitution. On the other hand, similar substitution of the standard ration by kernel powder significantly decreased body weight gains when compared to the control. The MLD and LD50 in mice were 10 and 15.7 gm/kg body weight, respectively for the mesocarp and were 20 and 27.7 mg/kg body weight for the kernel. In chicks, the MLD and LD50 were 40.2 and 10.36 gm/kg body weight, respectively, for the mesocarp and were 8.4 and 12.4 gm/kg body weight for the kernel. The mesocarp and kernel alcoholic and watery extracts resulted in stimulation of the intestinal motility in rabbits. While the mesocarp extracts inhibited uterine motility, the kernel extracts stimulated it. Both mesocarp and kernel of B. aegyptiaca were devoid of presentational and oestrogenic effects. The kernel had androgenic effect. Both kernel and mesocarp of the plant fruit contained saponins, tannins and glycosides. Resins and alkaloids were present in the kernel. When Balanites kernel and mesocarp were incorporated in the diet of chicks at 20%, significant histopthologicaI changes were seen in the vital organs and included catarrhal enteritis, hepatic fatty change and individual cell necrosis and degeneration of the cells of the renal tubules. No uterine proliferate changes were found in rabbits which received daily subcutaneous injections of 200 and 400 mg of alcohol extracts of kernel and mesocarp for 5 days.
URI: http://khartoumspace.uofk.edu/handle/123456789/14445
Date: 2015-06-23


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