University of Khartoum

Chemical Composition of Some Indigenous Plants and Toxicity of Cassia Occidentalis, Indigofera Hochstetteri and Tephrosia Apollinea to Goats.

Chemical Composition of Some Indigenous Plants and Toxicity of Cassia Occidentalis, Indigofera Hochstetteri and Tephrosia Apollinea to Goats.

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Title: Chemical Composition of Some Indigenous Plants and Toxicity of Cassia Occidentalis, Indigofera Hochstetteri and Tephrosia Apollinea to Goats.
Author: Hagir Bedawi Suliman, Suliman
Abstract: Clinical signs and lesions in Nubian goats caused by daily oral dosing with fresh leaves and dry seeds of Cassia occidentalis and fresh or dry shoots of Tephrosia apollinea and Indigofera hochstetteri were studied. The results of kidney and liver function tests were evaluated and correlated with the pathological changes. The main signs of Cassia poisoning were diarrhoea, inappetence, dyspnoea, staggering, ataxia and recumbency. The lesions consisted of haemorrhages and congestion in the heart, lungs, abomasum and spleen, catarrhal enteritis, hepatic fatty change and necrosis, splenic haemosiderosis, pulmonary emphysema, necrosis and/or degeneration of the epithelial cells of the renal convoluted tubules and packing of the glomeruli with endothelial and small round cells. These changes were accompanied by an increase in the activity of GOT and in concentrations of ammonia and urea and by a decrease in total protein and calcium in the serum. There was a decrease in the value of Hb, PCV and RBC and an increase in leukocyte counts. Total lipids were higher in the liver, kidney and heart of Cassia – poisoned goats. Reduced appetite, bloat, dyspnoea, incoordination of movement, anaemia, diarrhoea and recumbency were the major signs of Indigofera poisoning goats. The lesions comprised pulmonary oedema, congestion and haemorrhage, perineuronal vacuolation in the grey matter of the spinal cord, hepatic portal fibrosis, fatty change and dilatation of the sinusoids, degeneration of the cells of the renal convoluted tubules and congestion of the medullary rays and catarrhal enteritis and abomasitis. Changes in serum constituents were correlated with clinical, pathological and enzyme histochemical changes. The main lesions of Tephrosia poisoning in goats were dilatation of the renal tubules, perineuronal vacuolation in the cerebrum and spinal cord, centrilobular hepatocellular necrosis and fatty change, catarrhal enteritis and haemorrhage in the lungs, heart and intestinal lamina propria. These changes were accompanied by an increase in concentration of creatinine, urea and ammonia and in the activity of GOT and by a decrease in total protein levels in the serum. Leuocoytosis was due to an increase in the number of neutrophils. The changes in the red cell parameters indicated development of anaemia. The record of the chemical composition of plants forms the basis for further collection and detailed investigation.
URI: http://khartoumspace.uofk.edu/handle/123456789/14448
Date: 2015-06-23


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