University of Khartoum

Studies on Chemotherapy of Experimental Haemonchosis in Goats.

Studies on Chemotherapy of Experimental Haemonchosis in Goats.

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dc.contributor.advisor S. E. I. Adam- G. Tartour en_US
dc.contributor.author Um El Alim Abakar Idris, Idris
dc.date.accessioned 2015-06-23T09:13:00Z
dc.date.available 2015-06-23T09:13:00Z
dc.date.issued 2015-06-23
dc.date.submitted 1980
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/14486
dc.description.abstract Development of signs and lesions in the tissues and organs of Nubian goats orally infected with 200 to 1000 3rd larval stage of Haemonchus contortus was studied. Inappetence, soft faeces, dullness, rough coat and anaemia were the main signs of experimental haenmonchosis in goats. The major pathological changes were abomasitis and erosions in the abomasal mucosa, catarrhal enteritis, fatty change and necrosis of scattered hepatocytes, focal degeneration of the cells of the renal tubules, hydropericardium, hydroperitoneum and serous atrophy of the cardiac fat. Increase levels in activity of GOT and in concentrations of ammonia, potassium and creatinine and a decrease in total protein were detected in the serum. Viability of H. contortus eggs tested and faecal egg counts of goats and of adult worms in their abomasae were recorded. The anthelmintic activity of stronmisole, nematol and the powdered shoots of Artemisia herba-abla was investigated in experimental haemonochosis in Nubian goats which were infected with single doses of 200 to 1000 H. contortus larvae. Goats were treated with single doses of 3.5, 7 and 15 ml of nematol and the clinical and pathological changes associated with successful therapy of H. contortus were described. Although post- treatment faecal egg counts were negative in some of the treated goats, post- mortem examinations showed that A. herba-alba at doses of 2.5 and 10 g was not completely effective against H. contortus. Stronmisole, at single doses of 40 and 80 mg/ kg was effective in eliminating H. contortus in goats but retreatment in 3 weeks was found to be necessary for the most effective therapy. Stronmisole at single or repeated doses of 240 mg/ kg was toxic to goats and caused widespread haemorrhages, sanguineous fluid in the peritoneal cavity, hepato-cellular necrosis and degeneration of the cells of the renal convoluted tubules. These changes were accompanied by an increase in the activity of GOT and in concentration of ammonia, urea and potassium and decrease in the level of total protein in the serum en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject Studies on Chemotherapy of Experimental Haemonchosis in Goats en_US
dc.title Studies on Chemotherapy of Experimental Haemonchosis in Goats. en_US
dc.type Thesis en_US
dc.Degree M.Sc en_US
dc.Faculty Veterinary Science en_US

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