University of Khartoum

Risk factors of Hepatitis C Virus Infection among Heamo-dialysis patients in Khartoum Hospital Dialysis Centre (KHDC) and Dr. Salma Suliman's Dialysis Centre (SDKTC), 2007

Risk factors of Hepatitis C Virus Infection among Heamo-dialysis patients in Khartoum Hospital Dialysis Centre (KHDC) and Dr. Salma Suliman's Dialysis Centre (SDKTC), 2007

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Title: Risk factors of Hepatitis C Virus Infection among Heamo-dialysis patients in Khartoum Hospital Dialysis Centre (KHDC) and Dr. Salma Suliman's Dialysis Centre (SDKTC), 2007
Author: Ali, Samah
Abstract: End stage renal failure and the need for maintanence heamo-dialysis has reached alarming levels in Sudan, judged by that the waiting list for renal transplantation is growing and so is the heamodialysis population. The problems associated with heamodialysis are also on the rise. Among these problems is viral hepatitis infection, particularly blood bourne viruses such as Hepatitis B and C. Prevalence of Hepatitis C Virus seropositivity is estimated to be 34 % in previous studies. This study aims at weighing the importance of different risk factors contributing to acquiring infection with Hepatitis C Virus, among heamo-dialysis patients in two of the largest dialysis centres in Khartoum, in October 2007. The study was a cross sectional study, data was collected using a structured questionnaire, HCV seropositivity was either implied by the patient or by being isolated in separate dialysis machines. A total of 120 patients from both centres: 81 (67.5%) in SDKTC and 39 (32.5%) KDC were included in the study,73 (61 % )were males, 47 (39 %) were females. The mean age was 42.4 ± 16.0 years. The causes of Renal Failure were miscallenous, but were mainly Infections (i.e. Glomerulonephritis) in 33 % of cases and Hypertension in 24% of cases. The proportion of patients found to have HCV infection was 27.5 %. Only 4 patients were free of infection before commencement of heamo-dialysis, the rest seroconverted after dialysis. The mean duration of Heamo-dialysis was 47.84 ±39.6 months, (range 1 to 168 months). HCV infection was found to be significantly associated with longer duration of dialysis , previous surgery, previous blood transfusion, multi-centre dialysis (p= 0.000). No significant association was found between HCV infection and tattooing and needle sharing activities. The study concluded that although HCV seropositivity was lower than previously reported, it is still high among Heamodialysis patients in Sudan. Among other causes, nosocomial infection is a contributing factor. Viral hepatitis in heamodialysis patients is bearing a huge psychological burden on Renal Failure patients as well as a financial burden on dialysis centres.
URI: http://hdl.handle.net/123456789/1609
Date: 2008


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