University of Khartoum

Association of Eumycetoma and Schistosomiasis

Association of Eumycetoma and Schistosomiasis

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dc.contributor.author van Hellemond, Jaap J.
dc.contributor.author Vonk, Alieke G.
dc.contributor.author Vogel, Corne´ de
dc.contributor.author Koelewijn, Rob
dc.contributor.author Vaessen, Norbert
dc.contributor.author Fahal, Ahmed H.
dc.contributor.author van Belkum, Alex
dc.contributor.author van de Sande, Wendy W. J.
dc.date.accessioned 2015-10-01T09:15:58Z
dc.date.available 2015-10-01T09:15:58Z
dc.date.issued 2013-05
dc.identifier.citation van Hellemond JJ, Vonk AG, de Vogel C, Koelewijn R, Vaessen N, et al. (2013) Association of Eumycetoma and Schistosomiasis. PLoS Negl Trop Dis 7(5): e2241. doi:10.1371/journal.pntd.0002241 en_US
dc.identifier.issn 1935-2727
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/16350
dc.description.abstract Eumycetoma is a morbid chronic granulomatous subcutaneous fungal disease. Despite high environmental exposure to this fungus in certain regions of the world, only few develop eumycetoma for yet unknown reasons. Animal studies suggest that co-infections skewing the immune system to a Th2-type response enhance eumycetoma susceptibility. Since chronic schistosomiasis results in a strong Th2-type response and since endemic areas for eumycetoma and schistosomiasis do regionally overlap, we performed a serological case-control study to identify an association between eumycetoma and schistosomiasis. Compared to endemic controls, eumycetoma patients were significantly more often sero-positive for schistosomiasis (p = 0.03; odds ratio 3.2, 95% CI 1.18–8.46), but not for toxoplasmosis, an infection inducing a Th1-type response (p = 0.6; odds ratio 1.5, 95% CI 0.58–3.83). Here, we show that schistosomiasis is correlated to susceptibility for a fungal disease for the first time. en_US
dc.publisher POLS Neglected Tropical Diseases en_US
dc.relation.ispartofseries POLS Neglected Tropical Diseases;Volume 7,Issue 5 , e2241
dc.subject Mycetoma en_US
dc.subject Schistosomiasis en_US
dc.subject Serology en_US
dc.subject Schistosoma en_US
dc.subject Infectious Disease Surveillance en_US
dc.title Association of Eumycetoma and Schistosomiasis en_US
dc.type Article en_US

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