University of Khartoum

Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma

Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma

Show simple item record

dc.contributor.author Ahmed, Sarah Abdalla
dc.contributor.author Fahal, Ahmed H.
dc.contributor.author etal
dc.date.accessioned 2015-10-07T06:13:46Z
dc.date.available 2015-10-07T06:13:46Z
dc.date.issued 2013-05-16
dc.identifier.citation de Hoog GS, Ahmed SA, Najafzadeh MJ, Sutton DA, Keisari MS, Fahal AH, et al. (2013) Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma. PLoS Negl Trop Dis 7(5): e2229. doi:10.1371/journal.pntd.0002229 en_US
dc.identifier.issn 1935-2727
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/16420
dc.description.abstract Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis is one of the prevalent etiologic agents in arid Northeastern Africa. The source of infection has not been clarified. Subcutaneous inoculation from plant thorns has been hypothesized, but attempts to detect the fungus in relevant material have remained unsuccessful. The present study aims to find clues to reveal the natural habitat of Madurella species using a phylogenetic approach, i.e. by comparison of neighboring taxa with known ecology. Four species of Madurella were included in a large data set of species of Chaetomium, Chaetomidium, Thielavia, and Papulaspora (n = 128) using sequences of the universal fungal barcode gene rDNA ITS and the partial LSU gene sequence. Our study demonstrates that Madurella species are nested within the Chaetomiaceae, a family of fungi that mainly inhabit animal dung, enriched soil, and indoor environments. We hypothesize that cattle dung, ubiquitously present in rural East Africa, plays a significant role in the ecology of Madurella. If cow dung is an essential factor in inoculation by Madurella, preventative measures may involve the use of appropriate footwear in addition to restructuring of villages to reduce the frequency of contact with etiologic agents of mycetoma. On the other hand, the Chaetomiaceae possess a hidden clinical potential which needs to be explored. en_US
dc.publisher PLOS Neglected Tropical Diseases en_US
dc.relation.ispartofseries PLOS Neglected Tropical Diseases;Volume 7 | Issue 5 | e2229
dc.subject Madurella en_US
dc.subject Mycetoma en_US
dc.subject Fungi en_US
dc.subject Habitats en_US
dc.subject Phylogenetic analysis en_US
dc.subject Multiple alignment calculation en_US
dc.subject Phylogenetics en_US
dc.subject Sequence alignment en_US
dc.title Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma en_US
dc.type Article en_US

Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account