University of Khartoum

A Study on the Changes in the First-line Coagulation Screening Tests in Sudanese Sickle Cell Disease Patients requirement for the degree of Bachelor with honours in Haematology and Immunohaematology July

A Study on the Changes in the First-line Coagulation Screening Tests in Sudanese Sickle Cell Disease Patients requirement for the degree of Bachelor with honours in Haematology and Immunohaematology July

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Title: A Study on the Changes in the First-line Coagulation Screening Tests in Sudanese Sickle Cell Disease Patients requirement for the degree of Bachelor with honours in Haematology and Immunohaematology July
Author: Ahmed, Eiman Mohammed Angabo; Khalid, IbtihalSafwanZain Al-Abdeen; Mohammed, Kawthar Mohammed Ali; Mahmoud, Hadeel Salah Mohammed
Abstract: Sickle cell disease is an inherited disease characterized by a complex and varied physiopathology. Apart from the sickle red blood cells are responsible for vascular occlusion and hemolytic anemia. Changes in the coagulation system seem to play an important role in the clinical manifestations of this disorder. This study aimed to determine the changes in first-line coagulation screening tests in Sudanese sickler patients. Forty patients with SCD of both sexes with ages ranged between 9 months and 18 years, admitted to Um Durman Children Emergency Hospital from January to March 2011, were included in this cross-sectional study. These were either during crisis state or in the steady state. Eleven healthy controls matched with ages and genders of patients were used for comparison. Blood samples from both groups were collected and investigated for CBC, PT, aPTT, TcT, and Fbg concentrations. The study revealed that, in comparison with control means, the mean of Plts count was elevated (P=0.003), TcT and aPTT were significantly low (P=0.00) (P=0.013) respectively, while there were no significant changes in PT clotting times (P=0.641) and fibrinogen concentrations (P=0.212). These results were the same in patients during crisis and those in steady state. The study concluded that these is hypercoagulable state in SCD patients indicated by shortened TcT and aPTT clotting times, these findings were not associated with severity of the anaemia.
URI: http://khartoumspace.uofk.edu/123456789/16721
Date: 2011


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