University of Khartoum

Prevalence of Bleeding Disorders among Women Presenting with Menorrhagia in Khartoum Teaching Hospital

Prevalence of Bleeding Disorders among Women Presenting with Menorrhagia in Khartoum Teaching Hospital

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Title: Prevalence of Bleeding Disorders among Women Presenting with Menorrhagia in Khartoum Teaching Hospital
Author: Ali, Leena Mohamed Osman
Abstract: Menorrhagia is a common problem among females. It has many causes. It is common among patients with bleeding disorders and can be a presenting symptom. Objectives: To assess the prevalence of bleeding disorders among women with menorrhagia Study design and procedure: This is a cross-sectional descriptive study, coducted in Khartoum Hospital (Dec2007-Feb2008); 34 women aged between 13 and 43 years presenting with menorrhagia were studied, where the usual gynecological and endocrinal causes of bleeding were ruled out by a gynaecologist. These patients were investigated for haemostatic defects by doing; platelet count and finger prick platelet aggregation test, bleeding time, prothrombin time, activated partial thromboplastin time, and when appropriate thrombin time and factor assay and factor XIII screening. Factor VIII level, vWf antigen, were done for all patients. Results and discussion: Of the 34 women investigated, 56% (19 cases) had a bleeding disorder to account for their menorrhagia. Although a majority of patients with platelet disorders and von Willebrand s disease (vWd), (47%) and (32%) respectively, other rare coagulation factor deficiencies such as factor V (10.5%), and factor X (10.5%) were also found. Platelet disorders included count and function defects. History of bleeding from other sites, appeared as a significant finding, which might be used as a predictor for such a disorder in patients with menorrhagia. Family history of bleeding tendencies was not a predictive finding. Conclusion and recommendations: Patients with menorrhagia without a discernable cause, therefore, need evaluation for haemostatic disorders. This necessitate collaborate work between gynaecologists and haematologists, to exclude haemostatic abnormality. Especially before surgical intervention. vWd needs special consideration, since it might be missed by routine investigations. There should be a reliable, specialized laboratory in coagulation to reduce the discrepancy of results
Description: 92page
URI: http://khartoumspace.uofk.edu/123456789/16738
Date: 2015-10-26


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