University of Khartoum

Effects of Camel Urine on Testosterone Level and Protein Metabolism in Male Rats of Different Testosterone Levels

Effects of Camel Urine on Testosterone Level and Protein Metabolism in Male Rats of Different Testosterone Levels

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Title: Effects of Camel Urine on Testosterone Level and Protein Metabolism in Male Rats of Different Testosterone Levels
Author: Abdall, Dalia Abdalla Mohamed
Abstract: The aim of the present study was to evaluate the effect of oral administration of she-camel urine in rats of different testosterone levels. The influence of this treatment on protein metabolism and other important biochemical parameters was also explored. Twenty four adult wistar albino male rats were divided into four groups; high and low serum testosterone groups, prepared by subcutaneously injection of testosterone enanthate and intraperitoneally injection of lead acetate respectively for 21 days, and other two groups (normal testosterone and control group) were used without pre treatments. Then all groups except the control group were treated daily by an oral dose of 2 ml/100g body weight of she-camel urine for another 21 days. Rat’s body weight was measured and blood samples were taken, before camel urine treatment and weekly after camel urine, to determine the serum levels of testosterone, total protein, albumin, globulins, albumin/globulins ratio A/G ratio, aspartate aminotransferase AST, alanine aminotransferaseALT, creatinine and urea. The results in the present work showed that after the 1st two weeks, camel urine regulated the high and low serum testosterone levels as they returned to their normal values. At the same time, no change on testosterone level was seen in the group of normal testosterone level. In the 3rd week of treatment, all treated groups showed significant (p<0.01) increase in testosterone level compared to the previous week. The serum total protein and globulinsshowed gradual and significant (p< 0.01) increase after administration of camel urinein all treated groups. On the other hand the albumin level was unchanged after application of camel urine except of a gradual increase in the low testosterone group that became significant (p<0.05) only in the 3rd week. Albumin/globulin ratio showed lower values after camel urine administration, but the difference was significant (P <0.05) in the high testosterone group only. AST and ALT levels showed significantly (p <0.01) high values in the high and low testosterone rat groups, these levels were significantly (p<0.05) reduced after camel urine administration. The levels of these enzymes in the normal testosterone rat group were unaffected except for a temporary increase observed in the second week after camel urine treatment. Serum creatinine showed gradual and significant (p<0.05) increase in all groups treated by camel urine, and serum urea level increased significantly after 7 and 21 days of camel urine application in the normal and high testosterone groups, respectively. Camel urine treatment improved the rate of weight growth in rats compared to the pretreated period in high and low testosterone groups. The study concluded that camel urine can regulate serum testosterone levels and rectify the resulted changes accompanied abnormal hormone levels. After treatments with camel urine, the protein synthesis increased, protein degradation decreased, and all parameters related to protein metabolism and liver function returned to their normal levels
URI: http://khartoumspace.uofk.edu/123456789/16792
Date: 2015-10-28


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