University of Khartoum

Accuracy of Fine Needle Aspiration Cytology in Diagnosis of Palpable Breast Tumors in Sudanese Patients

Accuracy of Fine Needle Aspiration Cytology in Diagnosis of Palpable Breast Tumors in Sudanese Patients

Show full item record

Title: Accuracy of Fine Needle Aspiration Cytology in Diagnosis of Palpable Breast Tumors in Sudanese Patients
Author: Mohammed, Mugahid Abdelrhman Mobark
Abstract: Background: A palpable breast mass is the second common presenting problem regarding breast symptoms and fine needle aspiration cytology (FNAC) has been used for many decades to evaluate palpable breast lumps. The aim of this study is an attempt to evaluate the accuracy of FNAC in diagnosis of palpable breast masses in Sudanese patients in comparison to the gold standard histopathological method and to elicit common types of tumors, the common age affected and the relation between age and incidence of malignancy in palpable breast lumps. Materials and Methods: This is a descriptive prospective and retrospective study carried out in the histopathology laboratory in Khartoum Teaching Hospital in the period between Jan. 2012- June. 2013. Fifty cases, 35 of them were selected from the records of study area and 15 cases were seen in FNAC casualty. Patients having both FNAC and histopathology results were included. FNAC slides and histological sections were obtained then both examined under light microscope by the researcher and supervisor and correlated. The data was collected by questionnaire designed for this purpose and analyzed by Statistical package for social science. Results: FNAC finding showed the common age of presentation ranged between 10-29years (56%). In 33 patients (66%) the mass was in the left breast with a tumor size in 31 cases (62%) ranging between 2.5-5 cm in the greatest diameter. Thirty six cases (72%) were benign 10 cases (20%) were malignant, 2 cases (4%) were inflammatory and 2 cases (4%) were suspicious. While in histopathology 38 cases (76%) were benign, 11 cases (22%) were malignant and one case (2%) was inflammatory. The commonest type of tumor was fibroadenoma in 25 cases (50%) while malignant aspirates represent 10 cases (20%) with invasive ductal carcinoma account for 7 cases (14%) of them. In 44 cases (88%) FNAC diagnoses correlate with histopathology while 6 cases (12%) are not correlated. Four cases (8%) were diagnosed as fibroadenoma while in histopathology two of them were fibrocystic changes one was intraductal papilloma and one was tubular adenoma. One case (2%) was diagnosed as inflammatory cells while in histopathology it was intraductal papilloma. One case (2%) diagnosed as atypical cells was found to be ductal hyperplasia in histopathology. Fibroadenoma is the commonest tumor in age range between 10-29years while malignant tumors are the commonest tumor in age range between 50-69 years. The period between FNAC diagnosis and histopathology diagnosis is 3-6 months in 52 % of cases. In cases of benign tumors the accuracy of FNAC was 94%, sensitivity 94.5%, specificity 92.3%. Positive and negative predictive values were 97%, and 85.7% respectively. In malignant tumors FNAC has accuracy of 98%, sensitivity of 90.9%, specificity of 100%, positive and negative predictive values of 100%, and 97.5% respectively. Conclusion: FNAC of palpable breast tumors is an accurate screening test with high sensitivity and specificity. Fibroadenoma was the commonest tumor while the commonest malignant tumor was invasive ductal carcinoma. The left breast was more commonly affected. FNAC correlates with histopathology in high percentage of cases.
Description: 80 Pages
URI: http://khartoumspace.uofk.edu/123456789/16869
Date: 2015-11-03


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account