Title:
|
Interplay between AMA1 immunisation and parasite challenge leads to protection against malaria infection in rhesus macaques |
Author:
|
Abdel Hamid, Muzamil M.; J Remarque, Edmond; Faber, Bart W
|
Abstract:
|
Plasmodium knowlesi (Pk), a simian malaria parasite, is a
suitable primate model for Plasmodium falciparum (Pf),
and it was recently identified as the fifth human malaria
parasite [1]. To test the ability of yeast-expressed
PkAMA1 (Figure 1) to protect rhesus macaques upon
challenge with Pk, six healthy rhesus monkeys were
vaccinated with PkAMA1 and six control monkeys were
vaccinated with PfAMA1 formulated in an oil in water
adjuvant [2]. All monkeys received three i.m. vaccinations
at 4 week intervals |
URI:
|
http://khartoumspace.uofk.edu/123456789/16992
|
Date:
|
2015-11-12 |