Abstract:
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Binary polymorphisms associated with the non-recombining
region of the human Y chromosome (NRY) preserve the paternal
genetic legacy of our species that has persisted to the present,
permitting inference of human evolution, population
affinity and demographic history1. We used denaturing highperformance
liquid chromatography (DHPLC; ref. 2) to identify
160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious
genealogy of 116 haplotypes, several of which display
distinct population affinities based on the analysis of 1062
globally representative individuals. A minority of contemporary
East Africans and Khoisan represent the descendants of
the most ancestral patrilineages of anatomically modern
humans that left Africa between 35,000 and 89,000 years ago. |