University of Khartoum

Using some Natural Pharmaceutical Preparations in the Management of Subfertile Male Patients: a Clinical Trial

Using some Natural Pharmaceutical Preparations in the Management of Subfertile Male Patients: a Clinical Trial

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Title: Using some Natural Pharmaceutical Preparations in the Management of Subfertile Male Patients: a Clinical Trial
Author: Almaadheede, Husamuldeen Salim Mohammed Saeed Alnajar
Abstract: Background: The use of minerals, medicinal plants and natural animal products in the treatment of different diseases is as old as man himself. Zinc plays an important role in the reproductive system. Date palm pollen (DPP) used traditionally for treating subfertile patients may influence semen parameters. Zinc and date palm pollen need to be investigated for such uses in oligoasthenozoospermic (low sperm count and motility) and azoospermic (no sperms in semen) subfertile Sudanese male patients. Royal jelly (RJ) has been acknowledged to be an immunomodulator agent. In this study, royal jelly has been selected to be tested in isolated asthenozoospermic cases (low motile sperms inspite of normal sperm count) that could be caused by an autoimmune mechanism. Patients and Methods: The study was a single group pretest-posttest experimental prospective comparative self-control study. It was conducted on subfertile men with age range from 20-60 years at andrology clinic in the Reproductive Health Care Centre (RHCC) in Khartoum State. A total of ninety two patients were included. Patients were divided into three categories according to the clinical diagnosis of their subfertility condition. The oligoasthenozoospermic subfertile category which included thirty three patients was divided into two groups: Twelve patients were treated with zinc sulphate capsules (110 mg) twice daily while twenty one patients were treated with pollen of date palm (500 mg) twice daily. XV The azoospermic subfertile category include forty three patients was divided into two groups: Twenty four patients were treated with zinc sulphate capsule (110 mg) twice daily, the other nineteen patients were treated with pollen of date palm (500 mg) twice daily. The isolated asthenozoospermic subfertile category include sixteen patients were treated with royal jelly 1g dry powder twice daily. The treatment continued on all patients included in the research for three months. Oligoasthenozoospermic and azoospermic patients receiving zinc sulphate treatment were tested before and after the treatment for FSH and Testosterone hormonal levels, serum and semen zinc levels, semen analysis via Computerized Assisted Semen Analysis (CASA) dynamic analysis report I and II. Oligoasthenozoospermic and azoospermic patients who received DPP treatment were tested before and after the treatment for FSH and testosterone hormonal levels, semen analysis through CASA dynamic analysis report I and II. Isolated asthenozoospermic patients managed by RJ were tested before and after the treatment for semen analysis through CASA dynamic analysis report I and II, serum and semen detection of antisperm antibodies (ASA). Results: Zinc administration in oligoasthenozoospermic patients induced a significant increase in FSH (p≤0.001), Testosterone, serum and semen zinc level. FSH and semen zinc level in azoospermic patients after zinc treatment, increased by significant value (p≤0.001). Date palm pollen (DPP) administration in oligoasthenozoospermic patients induced significant increase in testosterone (p≤0.001). FSH in azoospermic patients after DPP XVI treatment, increased by a statistically significant value (p≤0.001). Both zinc and DPP induced significant changes (p≤0.001) towards improvement in the total and progressive sperm motility percentages measured in oligoasthenozoospermic patients by CASA dynamic analysis report I and II. RJ administration in isolated asthenozoospermic patients induced a significant increase (p≤0.001) in both total and progressive motility details. All the partitions of progressive motility have changed significantly (p≤0.001) towards improvement. Royal Jelly (RJ) as well induced a significant reduction (p≤0.001) of ASA (IgG type) in serum and semen after the three months treatment. Conclusion: The studied compounds, zinc as an essential mineral, DPP as a plant product and RJ as animal product might possess an augmenter effect in subfertile male patients and might improve the fertilization capacity of their sperms through multiple mechanisms of actions.
Description: 207 Page
URI: http://khartoumspace.uofk.edu/123456789/17020
Date: 2015-11-12


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