Abstract:
|
Post kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-γ. To
study interferon-γ pathways in PKDL, we genotyped 80 trios from the Masalit ethnic group for
polymorphisms at −470 ins/delTT, -270T/C, -56T/C and +95T/C in IFNGR1, and at −179G/A and
+874T/A in IFNG. No associations occurred at IFNG. Global association with haplotypes
comprising all 4 markers at IFNGR1 (χ2
10df = 21.97, P=0.015) was observed, associated with a
significant (χ2
1df=4.54, P=0.033) bias in transmission of the haplotype insTT T T T, and less
(χ2
1df=5.59, P=0.018) than expected transmission of insTT C C C. When compared with data on
malaria associations from The Gambia, the results suggest a complex pattern of haplotypic
variation at the IFNGR1 promoter locus associated with different infectious disease in African
populations that reflect the complex roles of IFN-γ in parasite killing versus inflammation and
pathogenesis. |