University of Khartoum

Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium fakiparum or P. vivax malaria and association with disease severity

Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium fakiparum or P. vivax malaria and association with disease severity

Show full item record

Title: Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium fakiparum or P. vivax malaria and association with disease severity
Author: JAKOBSEN, P. H.; JONES, S. MORRIS; R0NN, A.; HVIID, L.; THEANDER, T. G.; THEANDER, I.; BYGBJERG, I. C.; GREENWOOD, B. M.
Abstract: Increased serum concentrations of soluble intercellular adhesion molecule-i (sICAM-1), soluble endothelial leucocyte adhesion molecule-i (sELAM-1) and soluble vascular cell adhesion molecule-i (sVCAM-l) were detected in Danish malaria patients infected with sequestering Plasmodiumfalciparum or non-sequestering P. vivax parasites, as well as in patients with sepsis or meningitis. Levels of soluble adhesion molecules remained elevated in the P. falciparum patients for several weeks after initiation of treatment. Plasma concentrations of sICAM-1, sVCAM- and sELAM-I were higher in Gambian children with severe P.falciparum malaria than in children with mild malaria. Plasma levels of sVCAM-I and sELAM-l were significantly correlated. Plasma levels of sELAM-i and sVCAM-i may reflect endothelial inflammatory reactions and these reactions may be harmful for humans infected with malaria parasites.
URI: http://khartoumspace.uofk.edu/123456789/17092
Date: 2015-11-15


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account