University of Khartoum

Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium fakiparum or P. vivax malaria and association with disease severity

Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium fakiparum or P. vivax malaria and association with disease severity

Show simple item record

dc.contributor.author JAKOBSEN, P. H.
dc.contributor.author JONES, S. MORRIS
dc.contributor.author R0NN, A.
dc.contributor.author HVIID, L.
dc.contributor.author THEANDER, T. G.
dc.contributor.author THEANDER, I.
dc.contributor.author BYGBJERG, I. C.
dc.contributor.author GREENWOOD, B. M.
dc.contributor.editor Ibrahim M Elhassan en_US
dc.date 1994
dc.date.accessioned 2015-11-15T10:15:14Z
dc.date.available 2015-11-15T10:15:14Z
dc.date.issued 2015-11-15
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17092
dc.description.abstract Increased serum concentrations of soluble intercellular adhesion molecule-i (sICAM-1), soluble endothelial leucocyte adhesion molecule-i (sELAM-1) and soluble vascular cell adhesion molecule-i (sVCAM-l) were detected in Danish malaria patients infected with sequestering Plasmodiumfalciparum or non-sequestering P. vivax parasites, as well as in patients with sepsis or meningitis. Levels of soluble adhesion molecules remained elevated in the P. falciparum patients for several weeks after initiation of treatment. Plasma concentrations of sICAM-1, sVCAM- and sELAM-I were higher in Gambian children with severe P.falciparum malaria than in children with mild malaria. Plasma levels of sVCAM-I and sELAM-l were significantly correlated. Plasma levels of sELAM-i and sVCAM-i may reflect endothelial inflammatory reactions and these reactions may be harmful for humans infected with malaria parasites. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject malaria en_US
dc.subject Plasmodium fakiparum en_US
dc.subject plasma en_US
dc.title Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium fakiparum or P. vivax malaria and association with disease severity en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account