University of Khartoum

Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum

Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum

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Title: Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum
Author: CAVANAGH, DAVID R.; DOBAN˜ O, CARLOTA; ELHASSAN, IBRAHIM M.; MARSH, KEVIN; Elhassan,Ahmed M.; HVIID, LARS; KHALIL, E. AT TAHIR G.; THEANDER, THOR G.; ARNOT, DAVID E.; MCBRIDE, JANA S.
Abstract: Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119 are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.
URI: http://khartoumspace.uofk.edu/123456789/17096
Date: 2015-11-15


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