University of Khartoum

Genetics and visceral leishmaniasis Of mice and man

Genetics and visceral leishmaniasis Of mice and man

Show simple item record Ibrahim, Muntaser E. Mishra, Abhishek Sundar, Shyam
dc.contributor.editor en_US
dc.contributor.other Molecular Biology en_US 2009-06 2015-11-15T10:38:05Z 2015-11-15T10:38:05Z 2015-11-15 2015
dc.description.abstract Ninety percent of the 500,000 annual new cases of visceral leishmaniasis occur in India/ Bangladesh/Nepal, Sudan and Brazil. Importantly, 80-90% of human infections are sub-clinical or asymptomatic, usually associated with strong cell-mediated immunity. Understanding the environmental and genetic risk factors that determine why two people with the same exposure to infection differ in susceptibility could provide important leads for improved therapies. Recent research using candidate gene association analysis and genome-wide linkage studies (GWLS) in collections of families from Sudan, Brazil and India have identified a number of genes/regions related both to environmental risk factors (e.g. iron), as well as genes that determine type 1 versus type 2 cellular immune responses. However, until now all of the allelic association studies carried out have been underpowered to find genes of small effect sizes (odds ratios or OR<2), and GWLS using multicase pedigrees have only been powered to find single major genes, or at best oligogenic control. The accumulation of large DNA banks from India and Brazil now makes it possible to undertake genome-wide asscociation studies (GWAS), which are ongoing as part of phase two of the Wellcome Trust Case Control Consortium. Data from this analysis should seed research into novel genes and mechanisms that influence susceptibility to visceral leishmaniasis. en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject leishmaniasis; candidate genes; genome scans en_US
dc.title Genetics and visceral leishmaniasis Of mice and man en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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