University of Khartoum

In Vivo Switching between Variant Surface Antigens in Human Plasmodium falciparum Infection

In Vivo Switching between Variant Surface Antigens in Human Plasmodium falciparum Infection

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dc.contributor.author Staalsoe, Trine
dc.contributor.author Hamad, Amel A.
dc.contributor.author Hviid, Lars
dc.contributor.author Elhassan, Ibrahim M.
dc.contributor.author Arnot, David E.
dc.contributor.author Theander, Thor G.
dc.contributor.editor Ibrahim M Elhassan en_US
dc.date 2002
dc.date.accessioned 2015-11-16T06:49:24Z
dc.date.available 2015-11-16T06:49:24Z
dc.date.issued 2015-11-16
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17115
dc.description.abstract A semi-immune individual was retrospectively found to have maintained an apparently monoclonal and genotypically stable asymptomatic infection for months after clinical cure of a Plasmodium falciparum malaria episode. Before the attack, the individual had no antibodies to variant surface antigens (VSAs) expressed by an isolate (isolate A) obtained at the time of the episode or by a genotypically identical isolate (isolate B) obtained from the same individual 3 months later. Six weeks after the attack, a strong isolate A–specific VSA antibody response had developed in the complete absence of isolate B–specific antibodies. In contrast, plasma obtained 7 months after the attack contained high levels of VSA antibodies recognizing both isolates. This is the first direct evidence of in vivo switching between VSAs in human P. falciparum infection. Our results suggest that VSA switching is an important survival strategy of P. falciparum, enabling the parasite to persist despite protective, parasite-specific immune responses. en_US
dc.language.iso en en_US
dc.publisher The Journal Of Infectious Diseases en_US
dc.subject Human Plasmodium en_US
dc.subject Variant Surface Antigens en_US
dc.subject falciparum en_US
dc.title In Vivo Switching between Variant Surface Antigens in Human Plasmodium falciparum Infection en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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