University of Khartoum

Anti - Glucose Regulated Protein 78 (GRP78) antibody responses in Alum/ALM plus BCG vaccinee, visceral leishmaniasis, and Post Kala- azar Dermal leishmaniasis patients

Anti - Glucose Regulated Protein 78 (GRP78) antibody responses in Alum/ALM plus BCG vaccinee, visceral leishmaniasis, and Post Kala- azar Dermal leishmaniasis patients

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dc.contributor.author
dc.contributor.author Musa, Ahmed M.
dc.contributor.author Elhassan, Ahmed M.
dc.contributor.author Khalil, Eltahir Awad G.
dc.contributor.author and, etal
dc.contributor.editor Ibrahim M Elhassan en_US
dc.contributor.other Department of Molecular Biology en_US
dc.date 2008-02
dc.date.accessioned 2015-11-16T07:23:00Z
dc.date.available 2015-11-16T07:23:00Z
dc.date.issued 2015-11-16
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17123
dc.description.abstract Introduction: The Glucose Regulated Protein 78 (GRP78) of Leishmania donovani is considered to be one of the potential Leishmania vaccine candidates. Patients and methods: Using Enzyme-Linked Immunosorbent Assay (ELISA), we measured IgG antibody responses to GRP78 in 39 healthy Sudanese volunteers vaccinated with Leishmania Alum/ALM + BCG vaccine, 29 patients with visceral leishmaniasis (VL), and 26 patients with post kala-azar dermal leishmaniasis (PKDL). Results: There was, no significant statistical difference in plasma levels of GRP78 antibodies in immunized and control group (P=0.37). Furthermore, no significant statistical difference in the levels of GRP78 antibodies in the pre and post vaccination plasma samples (P=0.60). Plasma IgG levels to GRP78 was significantly higher in visceral leishmaniasis and PKDL patients compared with control group (P=0.00). Conclusion: This study concludes that Alum/ALM vaccine does not induce a Th2 type of immune response. It also demonstrated clearly that VL and PKDL are associated with elevation of anti-GRP 78 antibodies and that GRP78 ELISA can be used to confirm diagnosis of Leishmania infections based on the clinical presentation. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject antibodies en_US
dc.subject antileishmanial en_US
dc.subject Sudan en_US
dc.subject cutaneous en_US
dc.subject Immunize en_US
dc.title Anti - Glucose Regulated Protein 78 (GRP78) antibody responses in Alum/ALM plus BCG vaccinee, visceral leishmaniasis, and Post Kala- azar Dermal leishmaniasis patients en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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