University of Khartoum

Frequencies of BCR-ABL1 Fusion Transcripts among Sudanese Chronic Myeloid Leukemia Patients

Frequencies of BCR-ABL1 Fusion Transcripts among Sudanese Chronic Myeloid Leukemia Patients

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dc.contributor.author Ibrahim, Muntaser E.
dc.contributor.author Osman, Emad Aldin Ibrahim
dc.contributor.author Fadl-Elmula, Imad Mohamed
dc.contributor.author etal.
dc.contributor.editor en_US
dc.contributor.other Molecular Biology en_US
dc.date 2010-04
dc.date.accessioned 2015-11-16T10:10:40Z
dc.date.available 2015-11-16T10:10:40Z
dc.date.issued 2015-11-16
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17141
dc.description.abstract The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation. en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject BCR-ABL, chronic myeloid leukemia, Ph chromosome, Sudanese, RT-PCR en_US
dc.title Frequencies of BCR-ABL1 Fusion Transcripts among Sudanese Chronic Myeloid Leukemia Patients en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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