Title:
|
Genetic Characterization of wild-type Measles Viruses Circulating in Suburban Khartoum, 1997–2000 |
Author:
|
Mukhtar, Moawia M.; van de Bildt, M. W. G.; El Mubarak, H. S.; etal.
|
Abstract:
|
Measles remains endemic in many East African
countries, where it is often associated with high
morbidity and mortality. We collected clinical specimens
from Sudanese measles patients between July
1997 and July 2000. Sequencing of the 3« 456
nucleotides of the nucleoprotein gene from 33
measles virus (MV) isolates and 8 RNA samples
extracted from clinical specimens demonstrated the
presence of a single endemic MV strain with little
sequence variation over time (overall nucleotide
divergence of 0 to 1±3%). This was confirmed by
sequencing of the complete H gene of two isolates
from 1997 and two from 2000, in which the overall
divergence ranged between 0 and 0±5%. Comparison
with MV reference strains demonstrated
that the viruses belonged to clade B, genotype B3,
and were most closely related to a set of viruses
recently isolated in Nigeria. Our study demonstrates
a remarkable genetic stability of an endemically
circulating MV strain. |
URI:
|
http://khartoumspace.uofk.edu/123456789/17218
|
Date:
|
2015-11-18 |