University of Khartoum

Riparian Ecosystems in Human Cancers

Riparian Ecosystems in Human Cancers

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dc.contributor.author Alfarouk, Khalid Omer
dc.contributor.author Ibrahim, Muntaser E.
dc.contributor.author Brown, Joel S.
dc.contributor.author etal.
dc.contributor.other Molecular Biology en_US
dc.date 2013-01
dc.date.accessioned 2015-11-18T11:07:09Z
dc.date.available 2015-11-18T11:07:09Z
dc.date.issued 2015-11-18
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17229
dc.description.abstract Intratumoral evolution produces extensive genetic heterogeneity in clinical cancers. This is generally attributed to an increased mutation rate that continually produces new genetically defined clonal lineages. Equally important are the interactions between the heritable traits of cancer cells and their microenvironment that produces natural selection favoring some clonal ‘species’ over others. That is, while mutations produce the heritable variation, environmental selection and cellular adaptation govern the strategies (and genotypes) that can proliferate within the tumor ecosystem. Here we ask: What are the dominant evolutionary forces in the cancer ecosystem? We propose that the tumor vascular network is a common and primary cause of intratumoral heterogeneity. Specifically, variations in blood flow result in variability in substrate, such as oxygen, and metabolites, such as acid, that serve as critical, but predictable, environmental selection forces. We examine the evolutionary and ecological consequences of variable blood flow by drawing an analogy to riparian habitats within desert landscapes. We propose that the phenotypic properties of cancer cells will exhibit predictable spatial variation within tumor phenotypes as a result of proximity to blood flow. Just as rivers in the desert create an abrupt shift from the lush, mesic riparian vegetation along the banks to sparser, xeric and dry-adapted plant species in the adjacent drylands, we expect blood vessels within tumors to promote similarly distinct communities of cancer cells that change abruptly with distance from the blood vessel. We propose vascular density and blood flow within a tumor as a primary evolutionary force governing variations in the phenotypic properties of cancer cells thus providing a unifying ecological framework for understanding intratumoral heterogeneity. en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject riparian zone, terrestrial-aquatic interactions, tumor biodiversity, tumor cords, tumor ecosystems en_US
dc.title Riparian Ecosystems in Human Cancers en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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