University of Khartoum

Co-Introgression of Y-Chromosome Haplogroups and the Sickle Cell Gene Across Africa’s Sahel

Co-Introgression of Y-Chromosome Haplogroups and the Sickle Cell Gene Across Africa’s Sahel

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dc.contributor.author Ibrahim, Muntaser E.
dc.contributor.author Hassan, Hisham Y.
dc.contributor.author Hussain, Ayman
dc.contributor.other Molecular Biology en_US
dc.date 2007-12
dc.date.accessioned 2015-11-18T11:53:15Z
dc.date.available 2015-11-18T11:53:15Z
dc.date.issued 2015-11-18
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17234
dc.description.abstract The Sahel that extends from the Atlantic Ocean to the Ethiopian highland is a historical reservoir of Africa’s cultures and grandest populations and a known arena of ancient and recent migrations.We are interested in the issue whether such migrations were also carriers of genetic traits and whether this introgression could be associated with population genetic markers. Based on analysis of Y-chromosome haplogroups, we present evidence that the sickle gene, one of the major protective polymorphisms known in malaria, has in fact found its way only recently to the gene pool of the populations in eastern Sahel. We discuss the possible dynamics of the process and give estimates of the age of the introduction of the S allele into eastern Sahel. en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject Y-chromosome; haplogroups; sickle gene; Sudan en_US
dc.title Co-Introgression of Y-Chromosome Haplogroups and the Sickle Cell Gene Across Africa’s Sahel en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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