University of Khartoum

Effects of Single-Dose Praziquantel on Morbidity and Mortality Resulting from Intestinal Schistosomiasis

Effects of Single-Dose Praziquantel on Morbidity and Mortality Resulting from Intestinal Schistosomiasis

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Title: Effects of Single-Dose Praziquantel on Morbidity and Mortality Resulting from Intestinal Schistosomiasis
Author: Kheir,M M.;Baraka,O.Z.;Mukhtar,Moawia M.;Homieda,M.M.A
Abstract: The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection [400 eggs/g of faeces] from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high [community-wide, up to 11/100 infected patients with bleeding]. Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution - See more at: http://apps.who.int/iris/handle/10665/118947#sthash.Uy0OEmZY.dpuf
URI: http://khartoumspace.uofk.edu/123456789/17240
Date: 2015-11-19


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