University of Khartoum

Post-Kala-Azar Dermal Leishmaniasis in The Sudan: Peripheral Neural Involvement

Post-Kala-Azar Dermal Leishmaniasis in The Sudan: Peripheral Neural Involvement

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Title: Post-Kala-Azar Dermal Leishmaniasis in The Sudan: Peripheral Neural Involvement
Author: Elhassan, Ahmed M.; Ali, Mohamed S.; Eltoum, IsamA.
Abstract: Four patients developed post-kala-azar dermal leishmaniasis and neuritis (PKDL) 1 to 6 months following apparently successful treatment of kala-azar. The duration of the lesion varied between 1 month and nearly 5 years. The lesions were macules, papules, or nodules affecting the face, extremities, and trunk. The diagnosis was made by demonstration of the parasite in slit smear and biopsies and by a positive direct agglutination test (DAT). Histologically, the patients were found to have neuritis affecting the cutaneous nerves in the lesion only. The nerves showed a lymphohistiocytic infiltration and occasionally parasites. There was no impairment of sensation. Response to sodium stibogluconate was good. PKDL may simulate leprosy both clinically and pathologically.
URI: http://khartoumspace.uofk.edu/123456789/17273
Date: 2015-11-25


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