The Pharmacodynamic Interactions of Sodium Stibogluconate (SSG) and Paromomycin (PM) on Various Isolated Tissues Preparations

Abstract

In this study, sodium stibogluconate and paromomycin were investigated for their effects on isolated perfused rabbit heart, rabbit aortic strip and isolated intestine and rat uterus. When sodium stibogluconate was added to the isolated perfused rabbit heart it produced a slight increase in the force of heart contraction, where as paromomycin effect. The combination of 2 drugs increased the force of contraction slightly; this may be due to the effect of sodium stibogluconate. Both drugs have neither stimulatory nor inhibitory effect on the rabbit aortic strip and prior administration of each these drugs did not antagonize the stimulatory effect of noradrenaline in this organ, suggesting that they have no alpha antagonistic property. Both drugs either separately or in combination produce no effect on the rat uterus preparation wether in contracting or non contracting state. Similarly, the 2 drugs didn’t relax the contractile rat uterus. Similarly, the 2 drugs produced no effects on the isolated rabbit intestine.