University of Khartoum

T-Cell Responses in Human Leishmaniasis

T-Cell Responses in Human Leishmaniasis

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Title: T-Cell Responses in Human Leishmaniasis
Author: Elhassan, Ahmed M.; Kharazmi, A.; Gasim, S.
Abstract: In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-γ response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-γ production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-γ and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.
URI: http://khartoumspace.uofk.edu/123456789/17393
Date: 2015-12-01


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