University of Khartoum

Hepatoprotective and toxicity assessment of Cannabis sativa seed oil in Albino rat

Hepatoprotective and toxicity assessment of Cannabis sativa seed oil in Albino rat

Show full item record

Title: Hepatoprotective and toxicity assessment of Cannabis sativa seed oil in Albino rat
Author: EL Badwi, E.M, Musa.; E. A, Osman.; M. M, Dahab.
Abstract: The present study was carried out on forty, male and female Wister white (albino) rats weighting 100-150 gm(s) to elucidate the hepatoprotective and toxicological effect of Cannabis Sativa oil on liver and Kidneys to explore the side effect of the oil for 4 weeks for toxicological parameter and 10 day for hepatoprotective activity. A daily doses of Cannabis sativa oil (0.01 ml/kg, 0.1 ml/kg and 1 ml/kg body weight/rat administered orally to three groups of rats (each group includes 10 rats) successively where a group of ten rats was taken as a control group. However, the results of study showed hepatorenal lesions but not causing death. Extracts of C. sativa showed no signs of abnormalities and no mortalities among off spring rats. No changes in the physiological behaviors were observed throughout the experiment. Moreover, the sections taken were characterized by pale kidney, generalized fatty changes in the liver during the experimental period (4 weeks). Also, the oil was tested for the hepatoprotective activity, the hepatotoixicty produced by administration of CCl4 in paraffin oil 1:9 at a dose of 0.2 ml/kg for 10 days, was found to be inhibited by simultaneous oral administration of oil of Cannabis sativa seeds at a dose 1 and 0.5 ml/kg for 10 days, with evidence of decreased level of serum AST, ALT, ALP, and billirubin. In addition the concurrent administration of oil with CCl4 for 10 days masked the liver changes induced by the hepatotoxic compound observed in the control rats and comparable with the hepatoprotective effect of the standard drug Silymarin
URI: http://khartoumspace.uofk.edu/handle/123456789/17790
Date: 2015-12-17


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account