University of Khartoum

Haemato-biochemical Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Gentamicin-Induced Nephrotoxicity in Wistar Rats

Haemato-biochemical Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Gentamicin-Induced Nephrotoxicity in Wistar Rats

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dc.contributor.author Abdel Gadi, E.H.
dc.contributor.author Bakhiet, Amel Omer
dc.contributor.author El Badwi, Samia
dc.date 2012
dc.date.accessioned 2015-12-17T08:27:24Z
dc.date.available 2015-12-17T08:27:24Z
dc.date.issued 2015-12-17
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/17792
dc.description.abstract The haemato-biochemical effects of aqueous extract of Khaya senegalensis were tested against gentamicin induced nephrotoxicity in Wistar rats. Rats were divided into 6 groups of 5 rats each. All rats were treated orally for 8 days. Rats in group 1 served as control group and received distilled water at 2 mL kg-1/day, group 2 received distilled water at 2 mL kg-1 and received gentamicin 100 mg kg-1 intramuscularly for the last 5 days, groups 3 and 4 received the aqueous extract of K. senegalensis stem bark orally at 500 and 250 mg kg-1, respectively and on the last 5 days they received gentamicin at 100 mg kg-1 intramuscularly. Groups 5 and 6 received the aqueous extract of K. senegalensis alone at 500 and 250 mg kg-1, respectively. Red Blood Cell (RBC) count, Haemoglobin (Hb), Haematocrit (PCV), Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin Concentration (MCHC) were determined. Measurement of urea, creatinine, total protein and albumin were investigated. The kidney tissues were microscopically examined. Intramuscular administration of gentamicin to rats resulted in significant elevation of serum urea, creatinine, total protein and albumin with massive tubular necrosis and degeneration of renal cortical tubules. Oral administration of Khaya senegalensis at 250 and 500 mg kg-1 to rats significantly ameliorated the increase in serum urea, creatinine, total protein and albumin and similarly ameliorate the damage in the kidney tubules. This study suggested nephroprotective effect of Khaya senegalensis aqueous extract which may be due to antioxidant properties of the extract together with the phytochemical constituents of K. senegalensis. Haemato-biochemical Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Gentamicin-Induced Nephrotoxicity in Wistar Rats. Available from: https://www.researchgate.net/publication/276042269_Haemato-biochemical_Effects_of_Aqueous_Extract_of_Khaya_senegalensis_Stem_Bark_on_Gentamicin-Induced_Nephrotoxicity_in_Wistar_Rats [accessed Dec 17, 2015]. en_US
dc.publisher university of khartoum en_US
dc.subject Haemato-biochemical Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Gentamicin-Induced Nephrotoxicity in Wistar Rats en_US
dc.title Haemato-biochemical Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Gentamicin-Induced Nephrotoxicity in Wistar Rats en_US
dc.type Publication en_US
dc.Faculty Veterinary en_US

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