University of Khartoum

Nasal Carriage of Staphylococcus Aureus among Hospital Personnel in National Ribat Hospital-Khartoum-Sudan

Nasal Carriage of Staphylococcus Aureus among Hospital Personnel in National Ribat Hospital-Khartoum-Sudan

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Title: Nasal Carriage of Staphylococcus Aureus among Hospital Personnel in National Ribat Hospital-Khartoum-Sudan
Author: Ibrahim, Sara Osman Bader
Abstract: Background: Staphylococcus aureus is a Gram positive bacterium, usually exists in skin of human or nasal cavity. Existence in nasal cavity is considered a common health problem worldwide. Objectives: The present study was conducted to assess the nasal carriage of Staphylococcus aureus among hospital personnel in Elribat teaching Hospital , Khartoum Sudan. The antibiotic profile of the isolate was determind. The effectiveness of mupirocin in eradication of staphylococci in the nose was evaluated. Methods: This study was carried out during the period from January to March 2010 in Ribat Teaching Hospital. Ethical clearance was obtained from the hospital authorities and a verbal consent was taken from all participants . Nasal swabs were taken from each of 310 medical personnel. (participants in this study included : doctors, sisters, medical assistants, dieticians, nurses, and technicians). After culturing on mannitol salt agar for overnight incubation, probable staphylococcal isolates were identified and subjected to coagulase test and DNase test . Ten of nasal carrier participants applied mupirocin ointment 2% to the nose twice daily for 10 consecutive days. After treatment, nasal swabs were taken on day 5,10 and 45 to evalute eradication. Results: nasal staphylococcal carriage was determined in 40 (12.9%) participants only. In vitro susceptibility tests were performed using agar diffusion method. The antibiotic susceptibility of Staphlococcus aureus isolates was found to be as follows : All Staphlococcus aureus isolates were 100% resistant to pencillinG, ampicillin and amoxcillin. However, the isolates were suscepted to many antibiotics, their susceptibility to these antibiotics showed the following descending order : vancomycin 100%, ciprofloxacin 100%, co-trimoxazole 97.5%, amoxicillin- clavulanic acid 95%,oxacillin 92.5%, methicillin 92.5%, erythromycin 87.5% and doxycycline 82.5%. In this study only one isolate (2.5%) was found to be methicillin resistant (MRSA). Mupirocin eradicated 70% of the isolates after 5 days and 90% after 10 days. However after 45 days the eradication rate drops to 60% indicating recolonization . Conclusions:Staphylococcus aureus nasal carriage is a common health problem all over the world and methicillin resistant Staphylococcus aureus (MRSA) is an emerging problem in Sudan ,which requires further attention and control.
Description: 87page
URI: http://khartoumspace.uofk.edu/handle/123456789/17919
Date: 2015-12-22


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