University of Khartoum

Monocytes and Macrophages and Placental Malaria Infections in an Area of unstable Malaria Transmission in Eastern Sudan

Monocytes and Macrophages and Placental Malaria Infections in an Area of unstable Malaria Transmission in Eastern Sudan

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dc.contributor.author Salih, Magdi M.
dc.contributor.author Mohammed, Amal H
dc.contributor.author Mohmmed, Ahmed A.
dc.contributor.author Adam, Gamal K.
dc.contributor.author Elbashir, Mustafa I.
dc.contributor.author Adam, I.
dc.contributor.other Department of Histopathology and Cytology en_US
dc.date 2011
dc.date.accessioned 2016-01-05T09:51:40Z
dc.date.available 2016-01-05T09:51:40Z
dc.date.issued 2016-01-05
dc.date.submitted 2016
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/18209
dc.description.abstract Background: Maternal immunity is thought to play a major role in the increased susceptibility of pregnant women to Plasmodium falciparum malaria. Few studies exist on immunohistochemical characterization of the placental inflammatory infiltrate. The current study was conducted in Gadarif hospital in an area characterized by unstable malaria transmission in eastern Sudan. Method: Ninety three placentae were investigated for malaria histological changes and immunohistochemical study for monocytes and macrophages (CD68). Results: While 1(1.1%), 2(2.2%) and 20(21.5%) of the 93 placentae had acute, chronic and past malaria infections, 70(75.2%) had no malaria infections. Monocytes and macrophage (CD 68) were detected in 29 (31.2%) of these 93 placentae. Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections [11/23 (47.8%) vs. 18/70 (25.7%); P = 0.047] especially in placentae with past malaria infections. Placental malaria infections and monocytes and macrophages cells infiltration were not different between primiparae and multiparae. There was no significant difference in the birth weight between the women with placental malaria infections/monocytes and macrophages cells infiltration and those who had no placental malaria infections/cellular infiltrations. Conclusion: Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections. Neither placental malaria infections nor cellular infiltrates were associated with parity or lead to reduction of birth weight. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject macrophages en_US
dc.subject Malaria en_US
dc.subject eastern Sudan en_US
dc.title Monocytes and Macrophages and Placental Malaria Infections in an Area of unstable Malaria Transmission in Eastern Sudan en_US
dc.type Publication en_US
dc.Faculty Medical Laboratory Sciences en_US

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