University of Khartoum

A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants

A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants

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Title: A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants
Author: Yagi, Sakina; Khiralla, Afra
Abstract: To evaluate the total phenolic content (TPC) and total antioxidant capacity (TAC) of ethyl acetate extracts of 21 endophytic fungi isolated from five Sudanese medicinal plants: Calotropis procera (C. procera), Catharanthus roseus (C. roseus), Euphorbia prostrate (E. prostrata), Vernonia amygdalina (V. amygdalina) and Trigonella foenum-graecum (T. foenum-graecum). Methods: Crude extracts of endophytic fungi and their host plants were tested by classical Folin-Ciocalteu colorimetric method to determine the TPC, also TAC was estimated using DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging in vitro method. Results: Among the endophytes, endophytic fungus Aspergillus sp. from T. foenum-graecum seeds demonstrated the highest both total phenolic content in term of Gallic Acid Equivalent (89.9±7.1 mg GAE/g) and antioxidant activity for DPPH radical scavenging assay (IC50:18.0±0.1 μg/mL). A high positive linear correlation (R2=0.999 1) was found between TAC and TPC of endophytic fungi isolated from V. amygdalina. Conclusion: The present study revealed that some endophytic fungi from the five Sudanese medicinal plants could be a potential source of novel natural antioxidant compounds
URI: http://khartoumspace.uofk.edu/handle/123456789/19433
Date: 2016-02-25


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