University of Khartoum

Characterization of Nephrotoxic Agents of Aristolochia bracteolata Lam. by Hyphenated Techniques

Characterization of Nephrotoxic Agents of Aristolochia bracteolata Lam. by Hyphenated Techniques

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Title: Characterization of Nephrotoxic Agents of Aristolochia bracteolata Lam. by Hyphenated Techniques
Author: Khalafalla, EB; Khalid, SA
Abstract: Nephropathy is a progressive form of renal fibrosis that develops into urothelial carcinoma in some patients consuming certain herbal preparations containing any of the species of the genus Aristolochia. This subject has garnered increasingly medical attention especially after it has been established that nephrotoxicity is associated with the presence of nitrophenanthrene carboxylic acid derivatives known as aristolochic acids. This subject has gained further support after the US Food and Drug Administration (FDA) issued in 2001 a warning addressing both the public and physicians of the serious toxicity associated with these compounds. This situation warranted us to investigate the incidence of renal failure associated with the use of the root of Aristolochia bracteolata in Sudan and to subject it to a preliminary clinical epidemiological survey followed by an in-depth pharmacognostical and phytochemical analysis. The root of Aristolochia bracteolata which is commonly known in Sudan as “um galagil” is frequently used in the local traditional medicine as an anti-helmintic agent, an antidote for scorpion stings or snake bites and to treat malaria and a number of inflammatory conditions.
URI: http://khartoumspace.uofk.edu/handle/123456789/19581
Date: 2015


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