University of Khartoum

Characterization of Nephrotoxic Agents of Aristolochia bracteolata Lam. by Hyphenated Techniques

Characterization of Nephrotoxic Agents of Aristolochia bracteolata Lam. by Hyphenated Techniques

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dc.contributor.author Khalafalla, EB
dc.contributor.author Khalid, SA
dc.date.accessioned 2016-03-08T11:31:33Z
dc.date.available 2016-03-08T11:31:33Z
dc.date.issued 2015
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/19581
dc.description.abstract Nephropathy is a progressive form of renal fibrosis that develops into urothelial carcinoma in some patients consuming certain herbal preparations containing any of the species of the genus Aristolochia. This subject has garnered increasingly medical attention especially after it has been established that nephrotoxicity is associated with the presence of nitrophenanthrene carboxylic acid derivatives known as aristolochic acids. This subject has gained further support after the US Food and Drug Administration (FDA) issued in 2001 a warning addressing both the public and physicians of the serious toxicity associated with these compounds. This situation warranted us to investigate the incidence of renal failure associated with the use of the root of Aristolochia bracteolata in Sudan and to subject it to a preliminary clinical epidemiological survey followed by an in-depth pharmacognostical and phytochemical analysis. The root of Aristolochia bracteolata which is commonly known in Sudan as “um galagil” is frequently used in the local traditional medicine as an anti-helmintic agent, an antidote for scorpion stings or snake bites and to treat malaria and a number of inflammatory conditions. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject Hyphenated Techniques en_US
dc.subject Nephrotoxic Agents en_US
dc.title Characterization of Nephrotoxic Agents of Aristolochia bracteolata Lam. by Hyphenated Techniques en_US
dc.type Article en_US

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