University of Khartoum

Comparative physicochemical properties of effervescent ciprofloxacin tablets to conventional tablets brand

Comparative physicochemical properties of effervescent ciprofloxacin tablets to conventional tablets brand

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Title: Comparative physicochemical properties of effervescent ciprofloxacin tablets to conventional tablets brand
Author: Massaad, Ahmed M.A.M.; Shayoub, Mohammed E.A.
Abstract: Improvement of physicochemical properties of tablets and make quality control for them is the duty of pharmaceutical efforts, and the effervescent tablets are palatable dosage form for patient due to easy swallow and ability to mask the bitter taste for many drugs. Objectives Thus the study aimed to formulate ciprofloxacin hydrochloride as effervescent tablet and compare it with five locally marketed ciprofloxacin hydrochloride coated tablets (three local brands and two imported brands). Methodology The study was carried out at the Department of Pharmaceutics-Faculty of Pharmacy at the University of Khartoum, Omdurman Islamic University andNational Ribat University and the Department of Microbiology atOmdurman Ahlia University. The samples were selected from different batch numbers randomly and the physicochemical experiments were carried out according to monographs and microbiological sensitivity test was also done. The second part of the work was the formulation of the drug as an effervescent tablet by two methods (direct compression and wet granulation). The bitter taste was masked by saccharine as sweating agent, furthermore the effervescent effect of citric acid, tartaric acid and sodium bicarbonate lead to improve the taste of the drug. Also the Guar was used as binding agent lead to hide the taste. The vanillin which was used as favouring agent also enhances the palatability. Results and conclusion The formulated tablets passed all the fundamental testes in the monograph, and also microbiological sensitivity tests was done against (Escherichia coli, Salmonella typhi, Salmonella para typhi and staphylococcus aureus) and then the results were compared to select the suitable one. A comparison was done between two formulae of wet granulation method (the increase of binder concentration and die size change). This study showed that formulating the drug as effervescent tablet by wet granulation method (low binder) concentration and die cavity thirteen or twenty is the suitable one and that might lead to increase in the drug effectiveness, therapeutic effect and decrease the ciprofloxacin resistance as well as increase patient acceptability due to formulating the drug as effervescent tablet consideration to take into previous studies.
URI: http://khartoumspace.uofk.edu/handle/123456789/19597
Date: 2015


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