University of Khartoum

Stability of Co-amoxiclav and Ceftriaxone Reconstituted Injectable Solutions

Stability of Co-amoxiclav and Ceftriaxone Reconstituted Injectable Solutions

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Title: Stability of Co-amoxiclav and Ceftriaxone Reconstituted Injectable Solutions
Author: Hassan, A.A.A.; Nur, A.O.M.; Gad kareem, E.A
Abstract: In hospitalized neonates and infants suffering from severe infectious disease; the use of injectable antibiotics is essential. Co-amoxiclav and Ceftriaxone injection are among the widely used antibiot-ics in children due to their relative safety and wide spectrum of activity. Since doses depend on the nature of the disease, age and weight of the patient, in most neonates and infants only a part of the reconstituted solution or suspension is used for a single dose due to their relatively low weights. The remaining part of the preparation is usually discarded by virtue of unreliability in its stability, increasing the cost of the treatment on patients and health institutes. This study aims to investigate the effect ofintensity of temperature and light (indoor light) on the stability of reconstituted Co-amoxiclav and Ceftriaxone injectable solutions in order to use them in the most cost-effective manner. The room temperature adopted in this study was 30°C instead of the 25°C used by the manufacturer.
URI: http://khartoumspace.uofk.edu/handle/123456789/19610
Date: 2015


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