University of Khartoum

The Role of Therapeutic Plasma Exchange in Clinical Neurology

The Role of Therapeutic Plasma Exchange in Clinical Neurology

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dc.contributor.author Seidi, Osheik
dc.date.accessioned 2016-03-09T06:34:11Z
dc.date.available 2016-03-09T06:34:11Z
dc.date.issued 2015
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/19625
dc.description.abstract Plasma exchange (PLEX) was first used in humans therapeutically about 1968. It entails separation of the cellular components of the blood from the plasma and re-infusing the cells in a replacement fluid. The latter is ideally 5% albumin but donor’s fresh frozen plasma, and alkaloids could be used. It has proven role in many neurological disorders. This includes Guillain-Barre Syndrome, myasthenia gravis, chronic inflammatory Demyelinating poly- radiculoneuropathy (CIDP), neuromyelitis optica, Devic’s disease (NMO), thrombotic thrombocytopenic purpura (TTP), and rapidly progressive multiple sclerosis (MS). It has remarkable outcome in many antibody mediated neurological disorders including Limbic Encephalitis, Anti Voltage Gated Potassium channels antibodies b newer syndromes ranging from encephalopathy, Morvan’s syndrome and many cases of unexplained status epileptics. A large vein or central line (CVL) is needed. The number of sessions and the volume replaced is variable between patients and medical conditions. With few modifications it can be used for red cells exchange in sickle cell crises and reducing cholesterol in familial hypercholesterolaemia resistant to medical therapy. An over view of the procedure, its indications, side effects and uses in other medical conditions will be lightly touched on, but uses in neurology will be stressed on. This include illustrative cases with videos and images. Our local experience will be shown briefly. This presentation is aimed at all medical and supportive team members en_US
dc.publisher university of Khartoum en_US
dc.subject The Role of Therapeutic Plasma Exchange in Clinical Neurology en_US
dc.title The Role of Therapeutic Plasma Exchange in Clinical Neurology en_US
dc.type Article en_US

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