University of Khartoum

Protective Effect of Ethanolic Extract of Tamarindus indica Against CCl 4 Induced Liver Damage in Rats

Protective Effect of Ethanolic Extract of Tamarindus indica Against CCl 4 Induced Liver Damage in Rats

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Title: Protective Effect of Ethanolic Extract of Tamarindus indica Against CCl 4 Induced Liver Damage in Rats
Author: El Badwi, Samia M. A.; El Bagir, Nabiela M.; Amin, Ahmed E.
Abstract: The aim of this study is to investigate the effect the fruit pulp ethanolic extract of Tamarindus indica in protecting liver damage induced by CCL 4 Thirty Wistar rats were used and divided into 5 groups of 6 rats each, the first group served as control and was given orally vehicle saline at 1ml/kg/day, the second group acts as CCL4 control and received CCL to induced damage to the liver, the third group treated with ethanolic extract of Tamarindus indica at 150 mg/kg/day and CCL , the fourth group was treated with silymarin as standard drug and CCL4and the fifth group was treated with 150 mg/kg/day ethanolic extract of Tamarindus indica alone, the experiment continued for 5 days, liver enzymes, AST, ALT and ALP were recorded as well as total bilirubin, total protein and heamatological parameters include RBCs, Hb, PCV, MCV and MCHC were measured.We found that, the ethanolic extract of T. indicaameliorated the damage caused by CCLby lowering the levels of AST, ALT, ALP and the concentration of bilirubin and this effect was verified by improvement of histopathological picture in the livers of the group treated by the plant compared with the liver of CCL group which exhibited severe centrilobular necrosis and fatty vacuolation. The study indicates that, Tamarindus indica ethanolic extract possess hepatoprotective ingredients
URI: http://khartoumspace.uofk.edu/123456789/21777


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