University of Khartoum

Evaluation of Effects of Milk Lipid (Ghee) Supplementation and Thermal Environment on the Metabolic Profile of Alloxan-diabetic Rabbits (Oryctolagus cuniculus)

Evaluation of Effects of Milk Lipid (Ghee) Supplementation and Thermal Environment on the Metabolic Profile of Alloxan-diabetic Rabbits (Oryctolagus cuniculus)

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Title: Evaluation of Effects of Milk Lipid (Ghee) Supplementation and Thermal Environment on the Metabolic Profile of Alloxan-diabetic Rabbits (Oryctolagus cuniculus)
Author: Ibrahim, Mariam Y; Elnageeb, Mohamed E.; Abdelatif, Abdalla M.
Abstract: The type of dietary fat and thermal environment may influence the metabolic profile and insulin sensitivity in normal and diabetic conditions. The objective of this study was to evaluate the effects of supplementation with anhydrous milk fat, ghee (FS) and season (summer vs winter) on blood metabolites and Body Weight (BW) in alloxan-diabetic and non-diabetic rabbits. In each season, twenty rabbits were assigned to 4 groups of 5 animals each. Two groups were rendered diabetic using alloxan monohydrate injection. Two groups, a normal and a diabetic received orally 2.5 g kg' b.wt. of ghee daily for 8 weeks. Blood samples collected weekly were used for determination of insulin and blood metabolite concentrations. During summer, insulin (INS) level for the diabetic and non-diabetic-fat supplemented (FS) rabbits was higher than the non-diabetic rabbits fed Lucerne. Diabetic FS rabbits had slightly higher INS level than diabetic group fed Lucerne. Glucose (GL) level was significantly higher in diabetic groups and GL level of FS diabetic rabbits was significantly higher than respective values of diabetic group fed Lucerne only. GL level of diabetic groups was significantly higher in summer. In both seasons, serum total lipids (TL) was significantly higher in diabetic than non-diabetic groups. TL was significantly higher in FS diabetic group in summer. FS increased triglyceride (TG) levels in diabetic and non-diabetic animals, TG level was significantly lower in winter in non-diabetic groups of rabbits. In both seasons, the FS diabetic significantly higher serum cholesterol (CHOL) level than the diabetic control and non-diabetic groups of rabbits. The CHO L evel in FS non-diabetic rabbits was significantly higher during winter. In both seasons, serum urea (UR) level was significantly higher in diabetic groups. Diabetic groups showed significantly higher UR during winter compared to summer values. Creatinine (CR) level of FS nondiabetic group was higher during summer. During summer, diabetic groups showed significantly lower mean BW than non-diabetic groups, while with FS, non-diabetic group showed significantly greater mean BW than the other groups. Diabetic FS group had significantly lower mean BW during winter. The findings have implications in pathophysiology and nutritional management of DM.
URI: http://khartoumspace.uofk.edu/123456789/21813


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