University of Khartoum

Effects of subclinical hypothyroidism on important serum lipids values of Sudanese women

Effects of subclinical hypothyroidism on important serum lipids values of Sudanese women

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Title: Effects of subclinical hypothyroidism on important serum lipids values of Sudanese women
Author: Ibrahim, Mohammad Madani; Elbagir, Nabiela M.; etal
Abstract: ObjectiveSubclinical thyroid dysfunction has significant impact on human health, as it is associated with disturbed lipid metabolism and cardiovascular disease. However these findings vary among different populations. Therefore it is important to examine the association between subclinical hypothyroidism and lipid levels in Sudan. MethodsBlood samples were collected from subclinical hypothyroid patients (n= 40), and healthy subjects (n= 40). Free triiodothyronine (T3), thyroxin (T4), and thyroid stimulating hormone (TSH) were measured by radioimmunoassay. Serum total cholesterol (Ch), triglycerides (TG), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) were analyzed by colorimetric method.ResultsAmong subjects with subclinical hypothyroidism, there was a significant increase (P<0.001) in the levels of total Ch, and TG when compared with the controls. The LDL-C levels were also found to be high in the subclinical hypothyroid group (P<0.03). No differences in the levels of HDL-C were observed among the study groups. ConclusionAccording to the obtained results, subclinical hypothyroidism can significantly increase the levels of most serum lipids including total Ch, LDL-C, and TG. Lipid abnormalities can suggest a possible link between subclinical thyroid dysfunction and cardiovascular diseases.
URI: http://khartoumspace.uofk.edu/123456789/21825


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