University of Khartoum

Effects of Alloxan-Induced Diabetes Mellitus on Blood Metabolites and Serum Minerals and Hormones in Rabbits (Lepus cuniculus) in Relation to Starch Supplementation and Season

Effects of Alloxan-Induced Diabetes Mellitus on Blood Metabolites and Serum Minerals and Hormones in Rabbits (Lepus cuniculus) in Relation to Starch Supplementation and Season

Show simple item record

dc.contributor.author Ibrahim, Mariam Y
dc.contributor.author Abdelatif, Abdalla Mohamed
dc.contributor.other Department of Physiology en_US
dc.date 2011
dc.date.accessioned 2016-06-13T09:53:29Z
dc.date.available 2016-06-13T09:53:29Z
dc.date.submitted 2016-06-13
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/21889
dc.description.abstract Abstract: The objective of the present study was to evaluate the effects of starch supplementation and season (summer vs winter) on blood metabolites and certain minerals and hormones in alloxan-diabetic and normal nondiabetic rabbits. In both seasons,alloxan induced significant lowering of serum insulin level associated with significantly higher plasma glucose levels. Starch supplementation increased insulin and glucose levels significantly in both seasons. Diabetes significantly decreased serum albumin level during winter. Diabetic rabbits had significantly higher serum urea levels in both seasons; non-diabetic rabbits had significantly higher urea level during winter compared to summer values. Non-diabetic rabbits fed Lucerne only had significantly higher creatinine levels that were significantly higher in summer than winter in all experimental groups. In both seasons, diabetic rabbits had higher serum total lipids levels. Starch supplementation caused significant increase in triglyceride level in summer. Diabetic-starch supplemented rabbits had significantly higher serum cholesterol level compared to other groups. With lucerne feeding, diabetic rabbits had significantly higher cholesterol level compared to non-diabetic state. Cholesterol was significantly higher during summer than winter in diabetic starch supplemented rabbits and in non-diabetic rabbits. In both seasons, diabetic rabbits fed Lucerne maintained significantly higher serum Na level compared to other experimental groups; Na level was significantly higher in diabetic- starch supplemented and non-diabetic rabbits during winter compared to respective summer values. Non-diabetic starch supplemented rabbits had significantly higher serum K level in winter compared to summer values.Non-diabetic starch supplemented rabbits had higher cortisol level in summer compared to winter. Diabetic-starch supplemented rabbits had significantly higher cortisol level compared to other groups in winter. Cortisol level was significantly higher in winter compared to summer values in diabetic rabbits. The findings have relevance for understanding pathophysiological changes in human diabetes. en_US
dc.publisher UOFK en_US
dc.subject Rabbits en_US
dc.subject Diabetes Mellitus en_US
dc.subject Starch Supplementation en_US
dc.subject Season en_US
dc.subject Blood metabolites en_US
dc.subject Minerals en_US
dc.subject Hormones en_US
dc.title Effects of Alloxan-Induced Diabetes Mellitus on Blood Metabolites and Serum Minerals and Hormones in Rabbits (Lepus cuniculus) in Relation to Starch Supplementation and Season en_US
dc.type Article en_US
dc.Faculty Veterinary en_US

Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account