University of Khartoum

Adulteration of aphrodisiac preparations with Sildenafil Citrate and Tadalafil used by Herbalists

Adulteration of aphrodisiac preparations with Sildenafil Citrate and Tadalafil used by Herbalists

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Title: Adulteration of aphrodisiac preparations with Sildenafil Citrate and Tadalafil used by Herbalists
Author: Saeed, Safa Mohammed Ahmed
Abstract: Background Being available and perceived safe herbal preparations for sexual dysfunction has increasingly been used by Sudanese patients. Recently, repeated complaints about side effects (such as headaches, flushing of the face, upset stomach and nasal congestion) similar to those of Sildenafil and Tadalafil, have been disclosed by some patients who were on such herbal preparations. Based on this, it was suggested that such herbal preparations were adulterated with Sildenafil and Tadalafil. The aim of this study was to assess the extent of Sildenafil and Tadalafil contained in these herbal preparations. Methodology: Thirty different herbal products claimed to enhance sexual activity were collected equally from street vendors, local practitioners, honey centers, herbal centers and licensed companies. Samples taken from street vendors, local practitioners and herbal centers were found in powder form packaged in plastic sacs .Those taken from honey centers were packaged in plastic bottles and samples collected from herbal companies were found in form of tablets ( packaged in plastic bottles) and capsules ( packaged in strips form ) without any label. Collected samples were screened for Sildenafil Citrate and Tadalafil using thin layer chromatography and adopted high performance liquid chromatography as qualitative and quantitative methods, respectively. Results TLC analysis revealed that 40% of the tested samples were found to be adulterated with Sildenafil Citrate and Tadalafil (3:1). HPLC analysis revealed that in a single dose of the adulterated samples 165.46 ± 0.79 mg of Sildenafil Citrate or 60.76 ± 0.60 mg of Tadalafil were detected. Conclusion Detection of Sildenafil Citrate (>165 mg) and Tadalafil (>60 mg) in 40% of the tested samples could explain the side effects reported by patients on these herbal preparations. Knowing that the maximum daily dose is 100 mg for Sildenafil Citrate and 20 mg for Tadalafil, repeated use of these preparations could result in fatal side effects.
Description: 128 Pages
URI: http://khartoumspace.uofk.edu/123456789/22059


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