University of Khartoum

Effect of Altered Thyroid Status in the Domestic Rabbit (Lepus cuniculus) on Thermoregulation, Heart Rate and Immune Responses

Effect of Altered Thyroid Status in the Domestic Rabbit (Lepus cuniculus) on Thermoregulation, Heart Rate and Immune Responses

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Title: Effect of Altered Thyroid Status in the Domestic Rabbit (Lepus cuniculus) on Thermoregulation, Heart Rate and Immune Responses
Author: Abdelatif, Abdalla Mohamed; Saeed, Intisar H.
Abstract: Fifteen Male rabbits were used to study the effects of thyroid status on thermoregulation, body weight (BW), heart rate (HR) and immunological responses. Hyperthyroidism was induced by subcutaneous injection of thyroxine (T4) (30 μg/ kg BW /day) while hypothyroidism was induced with oral administertion of carbimazole (CBZ) (30 mg/ animal/day). The treatments were administered for 28 days. Animals receiving (T4) and (CBZ) and the control group were immunized each with a single intravenous dose of sheep red blood cells (SRBCs) at day 16. Serum samples were obtained from blood samples collected from the rabbits at days 0, 4, 8 and 12 after immunization and haemagglutination antibody titres were determined. (T4) increased rectal temperature, respiratory rate, heart rate, total leukocyte count and antibody titre, while (CBZ) resulted in a decrease in these parameters compared with control values. (T4) decreased (BW) and increased spleen, heart and liver weights, while (CBZ) increased (BW), spleen, heart and liver weights compared with control values.
URI: http://khartoumspace.uofk.edu/123456789/22182


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