University of Khartoum

Detection of Micro Invasion In Verrucous Carcinoma Using Syndecan-1 Stain

Detection of Micro Invasion In Verrucous Carcinoma Using Syndecan-1 Stain

Show full item record

Title: Detection of Micro Invasion In Verrucous Carcinoma Using Syndecan-1 Stain
Author: Elhassan, Aisha Khidir Babiker
Abstract: Background: Verrucous carcinoma (VC) is a low grade rare variant of Squamous Cell Carcinoma (SCC). Syndecan-1 is a heparan sulfate proteoglycan which participates in cell to cell adhesion and cell matrix interaction. This study aimed to describe the histopathological features of VC on Hematoxyline and Eosin (H&E) and assess syndecan-1 expression in VC cases. This was an observational analytical study of 34 paraffin blocks of specimens of oral VC retrieved from The Oral Pathology Laboratory, Faculty of Dentistry University of Khartoum in the period (2006-2014). Methods: The study involved 34 paraffin blocks specimens of oral VC cases. Relevant clinical data were retrieved from the archive of the laboratory. Two control groups are used for syndecan-1 IHC consisting of 24 paraffin blocks specimens of different grade of oral epithelial dysplasia and 9 paraffin blocks specimens of normal oral mucosa. Results: On H&E examination about half of cases showed the classical features of VC and the other half showed some cytological changes and minute foci suggestive micro-invasion. There was variation in syndecan-1 intensity; The majority of the VC cases (94.1%) showed loss of syndecan-1 expression and loss was greater than loss in dysplastic control group which showed loss of syndecan-1 expression in (87.50%) of the cases. There was a change in the positivity area of syndecan-1 in (50.1%) of the VC cases. Sixty four per cent of the cases showed presence of foci of micro-invasion and of loss syndecan-1 expression. Conclusion: Highly statistically significant association was found between presence of suggestive micro-invasion in H&E and loss of syndecan-1 expression in micro-invasive area.
Description: 107 Pages
URI: http://khartoumspace.uofk.edu/123456789/22938


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account