University of Khartoum

Correlation between Serum Calcium Level and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Sudanese Patients in Khartoum State Sudan

Correlation between Serum Calcium Level and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Sudanese Patients in Khartoum State Sudan

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Title: Correlation between Serum Calcium Level and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Sudanese Patients in Khartoum State Sudan
Author: Musa, Safaa Abed ELRahman Hassan
Abstract: Association between diabetes and osteoporosis has been extensively investigated, as both diseases are very common and of great socioeconomic relevance. Hemoglobin A1c (HbA1c) is used routinely to monitor long-term glycemic control in people with diabetes mellitus, as HbA1c is related directly to risks for diabetic complications. A cross-sectional study was designed to evaluate the relation between serum calcium (Ca) and glycated hemoglobin (HbA1c) levels in type 2 diabetic Sudanese patients. Serum calcium levels and the HbA1c were estimated in patients and compared to control. Also the correlation between the two parameters was investigated with reference to the influence of age, gender and ethnicity of patients. The study was conducted on 40 diabetic patients (20males and 20 females); with mean of duration of diabetes of 10 years attended the Advanced Diagnostic Center clinic Khartoum North- Sudan and other 40 apparently healthy subjects were enrolled as control group. The age of the studied subjects ranged from 30 to 80 years for the two groups. The mean of age was as follows: diabetic group was 55 years and for the control group was 49 years. The serum level of Ca was measured by auto analyzer (Mindray-China - Bs-200) and the HbA1c was measured by CERA-STAT ™ 4000 analyzer (Korea). Serum Ca concentration was found to be significantly (P<0.01) lower in diabetic patients of 8.89 mg/dl and ranged from 7.5 to10.6 mg/dl when compared with the control group of 9.52 mg/dl and ranged between 9.0 and 11.5 mg/dl). Whereas, HbA1c percentage was found to be significantly (P<0.01) higher in diabetic patients of mean of 7.42% and ranged between 3.5 and 10.9%, when compared with the respective control group with a mean value of 4.89 % and the range from 3.7 to 6.4%. A negative correlation was observed r = - 0.56 (P<0.01) between serum calcium level and HbA1c level in diabetic patients; whereas, there is no significant correlation within control group. Also there was statistically no significant difference between males and females diabetic patients or the control group concerning the serum Ca or the HbA1c levels. The study also showed no significant correlation between age and serum calcium levels or HbA1c levels in diabetic patients and control group. There was no statistical significance between different ethnicities in serum calcium level and HbA1c level in diabetic patients and in control group. Findings in the present work showed that the increase in HbA1c, in Sudanese diabetics of type 2 diabetes mellitus, is accompanied by a significant decrease in Ca serum level. This effect was not influenced by gender or age of patients. According to these results it is suggested that, a good control of glucose can avoid the decline in the blood Ca levels. Also further studies in larger groups are recommended to confirm these findings.
Description: 79 Pages
URI: http://khartoumspace.uofk.edu/123456789/24159


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